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Wei ZhangCepEsperu School of Medicine

Wei Zhang


Contact Information

Academic: -7508 | Department:

Email: [email protected]

Additional Languages


Enlightenment & Training

  • B.S., Peking University, 1985
  • M.S., U Tex-Houstn Grad Sch Biomd Sc, 1990
  • Ph.D., U Tex-Houstn Grad Sch Biomd Sc, 1992
Wei Zhang

Wei Zhang

Professor, Cancer Biology

Investigation Interests

Carrier Proteins; Neoplasm Invasiveness; Adenocarcinoma; Pancreatic Neoplasms; Gene Expression Regulation, Neoplastic
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Contact Information

Academic: -7508 | Department:

Email: [email protected]

Recent Publications

Incorporating blood-based liquid biopsy information into cancer staging: time for a TNMB system?. Yang M, Forbes ME, Bitting RL, O'Neill SS, Chou PC, Topaloglu U, Miller LD, Hawkins GA, Grant SC, DeYoung BR, Petty WJ, Chen K, Pasche BC, Zhang W.. Ann Oncol. 2018;29(2):311-323.

A mutational signature associated with alcohol consumption and prognostically significantly mutated driver genes in esophageal squamous cell carcinoma. Li XC, Wang MY, Yang M, Dai HJ, Zhang BF, Wang W, Chu XL, Wang X, Zheng H, Niu RF, Zhang W, Chen KX.. Ann Oncol. 2018;29(4):938-944.

A phase I study of CPI-613 in combination with high dose cytarabine and mitoxantrone for relapsed or refractory acute myeloid leukemia. Pardee TS, Anderson RG, Pladna KM, Isom S, Ghiraldeli LP, Miller LD, Chou JA, Jin G, Zhang W, Ellis LR, Berenzon D, Howard DS, Hurd D, Manuel M, Dralle S, Lyerly S, Powell BL.. Clin Cancer Res. 2018;():.

Favorable outcome of patients with lung adenocarcinoma harboring POLE mutations and expressing high PD-L1 [letter]. Liu L, Ruiz J, O'Neill SS, Grant SC, Petty WJ, Yang M, Chen K, Topaloglu U, Pasche B, Zhang W... Mol Cancer. 2018;17(1):81.

Pathogenic germline variants in 10,389 adult cancers. Huang KL, Mashl RJ, Wu YG, Ritter DI, Wang JY, Oh C, Paczkowska M, Reynolds S, Wyczalkowski MA, Oak N, Scott AD, Krassowski M, Cherniack AD, Houlahan KE, Jayasinghe R, Wang LB, Zhou DC, Liu D, Cao S, Kim YW, Koire A,.. Cell. 2018;173(2):355-70.e14.

Precision medicine becomes reality-tumor type-agnostic therapy. Yan L, Zhang W.. Cancer Commun (Lond). 2018;38(1):6.

Nuclear beta-catenin localization and mutation of the CTNNB1 gene: a context-dependent association. Kim G, Kurnit KC, Djordjevic B, Singh C, Munsell MF, Wang WL, Lazar AJ, Zhang W, Broaddus R.. Mod Pathol. 2018;():.

SPINK6 promotes metastasis of nasopharyngeal carcinoma via binding and activation of epithelial growth factor receptor. Zheng LS, Yang JP, Cao Y, Peng LX, Sun R, Xie P, Wang MY, Meng DF, Luo DH, Zou X, Chen MY, Mai HQ, Guo L, Guo X, Shao JY, Huang BJ, Zhang W, Qian CN.. Cancer Res. 2017;77(2):579-589.

MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer. Sun Y, Ji P, Chen T, Zhou X, Yang D, Guo Y, Liu Y, Hu L, Xia D, Liu Y, Multani AS, Shmulevich I, Kucherlapati R, Kopetz S, Sood AK, Hamilton SR, Sun B, Zhang W.. J Pathol. 2017;241(1):67-79.

Recombined humanized endostatin (Endostar) combined with chemotherapy for advanced bone and soft tissue sarcomas in stage IV. Xing P, Zhang J, Yan Z, Zhao G, Li X, Wang G, Yang Y, Zhao J, Xing R, Teng S, Ma Y, Liao Z, Ren Z, Zhang C, Han X, Zhang W, Chen K, Wang P, Yang J.. Oncotarget. 2017;8(22):36716-27.

MIR506 induces autophagy-related cell death in pancreatic cancer cells by targeting the STAT3 pathway. Sun L, Hu L, Cogdell D, Lu L, Gao C, Tian W, Zhang Z, Kang Y, Fleming JB, Zhang W.. Autophagy. 2017;13(4):703-714.

CTNNB1 (beta-catenin) mutation identifies low grade, early stage endometrial cancer patients at increased risk of recurrence. Kurnit KC, Kim GN, Fellman BM, Urbauer DL, Mills GB, Zhang W, Broaddus RR.. Mod Pathol. 2017;30(7):1032-1041.

The US Chinese Anti-Cancer Association and the Asian Fund for Cancer Investigation recognize young Chinese cancer researchers with the 2016 USCACA-AFCR scholar awards [editorial]. Zhang W, Yan L, Zhang W, Tong Y, Cheng SY.. Chin J Cancer. 2017;36(1):30.

Strong FGFR3 staining is a marker for FGFR3 fusions in diffuse gliomas. Granberg KJ, Annala M, Lehtinen B, Kesseli J, Haapasalo J, Ruusuvuori P, Yli-Harja O, Visakorpi T, Haapasalo H, Nykter M, Zhang W.. Neuro Oncol. 2017;19(9):1206-1216.

Genomic testing using cytology vs surgical specimens: a comparative study [abstract]. Steele RM, Topaloglu U, Miller LD, Zhang W, Pasche B, DeYoung BR, Qaseni SA [sic] Qasem SA.. Mod Pathol. 2017;30(Suppl 2):520A.

Genomic testing using cytology vs surgical specimens: a comparative study [abstract]. Steele RM, Tapaloglu U, Miller LD, Zhang W, Pasche B, DeYoung BR, Qasem SA.. Lab Invest. 2017;97(Suppl 1):520A.

Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial. Alistar A, Morris BB, Desnoyer R, Klepin HD, Hosseinzadeh K, Clark C, Cameron A, Leyendecker J, D'Agostino R Jr, Topaloglu U, Boteju LW, Boteju AR, Shorr R, Zachar Z, Bingham PM, Ahmed T, Crane S, Shah R, Migliano JJ, Pardee TS, Miller L,.. Lancet Oncol. 2017;18(6):770-778.

Clinical association analysis of ependymomas and pilocytic astrocytomas reveals elevated FGFR3 and FGFR1 expression in aggressive ependymomas. Lehtinen B, Raita A, Kesseli J, Annala M, Nordfors K, Yli-Harja O, Zhang W, Visakorpi T, Nykter M, Haapasalo H, Granberg KJ.. BMC Cancer. 2017;17(1):310.

Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages. Yang M, Topaloglu U, Petty WJ, Pagni M, Foley KL, Grant SC, Robinson M, Bitting RL, Thomas A, Alistar AT, Desnoyers RJ, Goodman M, Albright C, Porosnicu M, Vatca M, Qasem SA, DeYoung B, Kytola V, Nykter M, Chen K, Levine EA, Staren ED,.. J Hematol Oncol. 2017;10(1):100.

DNA methylation signatures and coagulation factors in the peripheral blood leucocytes of epithelial ovarian cancer. Li L, Zheng H, Huang Y, Huang C, Zhang S, Tian J, Li P, Sood AK, Zhang W, Chen K.. Carcinogenesis. 2017;38(8):797-805.

Haploinsufficiency and mutation are two sides of the cancer coin as cause and therapeutics target [editorial]. Song QQ, Zhang W, Sun Y.. Transl Cancer Res. 2017;6(Suppl 3):S590-S593.

Mutational landscapes of smoking-related cancers in Caucasians and African Americans: precision oncology perspectives at CepEsperu Baptist Comprehensive Cancer Center. Kytola V, Topaloglu U, Miller LD, Bitting RL, Goodman MM, D Agostino RB Jr, Desnoyers RJ, Albright C, Yacoub G, Qasem SA, DeYoung B, Thorsson V, Shmulevich I, Yang M, Shcherban A, Pagni M, Liu L, Nykter M, Chen K, Hawkins GA, Grant SC,.. Theranostics. 2017;7(11):2914-2923.

The 150 most important questions in cancer research and clinical oncology series: questions 57-66 [editorial]. Cao S, Xu Y, Zhang LN, Chen KX, Zhang W, Chen X, Yang M, Yang JP, Takahashi M, Ding ZY.. Chin J Cancer. 2017;36(1):79.

PKCepsilon phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation. Chen T, Li J, Xu M, Zhao Q, Hou Y, Yao L, Zhong Y, Chou PC, Zhang W, Zhou P, Jiang Y.. Nat Commun. 2017;8(1):939.

Estrogen and insulin synergistically promote type 1 endometrial cancer progression. Tian W, Teng F, Zhao J, Gao J, Gao C, Sun D, Liu G, Zhang Y, Yu S, Zhang W, Wang Y, Xue F.. Cancer Biol Ther. 2017;18(12):1000-1010.

Exon 3 mutations of CTNNB1 drive tumorigenesis: a review. Gao C, Wang Y, Broaddus R, Sun L, Xue F, Zhang W.. Oncotarget. 2017;9(4):5492-5508.

Targeting the FGFR3-TACC3 fusion: toward personalized medicine [abstract]. Kerrigan BP, Yamashita S, Kronowitz M, Ledbetter D, Gumin J, Phillips L, Hossain A, Zhang W, Lang F.. Abstr Pap Am Chem Soc. 2017;254():A544.

ADAMTS16 mutations sensitize ovarian cancer cells to platinum-based chemotherapy. Yasukawa M, Liu Y, Hu L, Cogdell D, Gharpure KM, Pradeep S, Nagaraja AS, Sood AK, Zhang W.. Oncotarget. 2016;8(51):88410-20.

IGFBP2 activates the NF-kB pathway to drive epithelial-mesenchymal transition and invasive character in pancreatic ductal adenocarcinoma. Gao S, Sun Y, Zhang X, Hu L, Liu Y, Chua YX, Phillips LM, Ren H, Fleming JB, Wang H, Chiao PJ, Hao J, Zhang W.. Cancer Res. 2016;76(22):6543-6554.

MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis. Wang Y, Hu L, Ji P, Teng F, Tian W, Liu Y, Cogdell D, Liu J, Sood AK, Broaddus R, Xue F, Zhang W.. J Hematol Oncol. 2016;9(1):112.

Glioma progression is mediated by an addiction to aberrant IGFBP2 expression and can be blocked using anti-IGFBP2 strategies. Phillips LM, Zhou X, Cogdell DE, Chua CY, Huisinga A, R Hess K, Fuller GN, Zhang W.. J Pathol. 2016;239(3):355-364.

Defeating cancer: the 150 most important questions in cancer research and clinical oncology [editorial]. Qian CN, Zhang W, Xu RH.. Chin J Cancer. 2016;35(1):104.

MiR-502/SET8 regulatory circuit in pathobiology of breast cancer. Liu B, Zhang X, Song F, Zheng H, Zhao Y, Li H, Zhang L, Yang M, Zhang W, Chen K.. Cancer Lett. 2016;376(2):259-267.

A functional single nucleotide polymorphism of SET8 is prognostic for breast cancer. Liu B, Zhang X, Song F, Liu Q, Dai H, Zheng H, Cui P, Zhang L, Zhang W, Chen K.. Oncotarget. 2016;7(23):34277-87.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cancer Biology

Wei Zhang

Wei Zhang

Professor, Cancer Biology

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