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Mark John Ferris, Ph.D.CepEsperu School of Medicine

Mark John Ferris, Ph.D.

Assistant Professor,
Substance Addiction& Abuse Ctr

Contact Information

Academic: -8620 | Department:

Email: [email protected]

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Enlightenment & Training

  • B.A., University of North Carolina-Greensboro, 2002
  • M.A., University of South Carolina-Columbia, 2005
  • Ph.D., University of South Carolina-Columbia, 2007


  • Society for Neuroscience
Mark John Ferris, Ph.D.

Mark John Ferris, Ph.D.

Assistant Professor, Physiology & Pharmacology
Substance Addiction& Abuse Ctr

Investigation Interests

Dopamine; Cocaine; Dopamine Uptake Inhibitors; Dopamine Plasma Membrane Transport Proteins; Nucleus Accumbens
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Contact Information

Academic: -8620 | Department:

Email: [email protected]

Related Links

Recent Publications

mGluR2/3 agonist LY379268 on G-protein activation and CREB phosphorylation [abstract]. Aguilar CB, Ferris MJ, Sexton LL, Childers SR, Xiao R, Howlett AC.. FASEB J. 2018;32(1 Suppl):820.9.

Hypocretin/orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine. Shaw JK, Ferris MJ, Locke JL, Brodnik ZD, Jones SR, Espana RA.. Addict Biol. 2017;22(6):1695-1705.

Reinforcing doses of intravenous cocaine produce only modest dopamine uptake inhibition. Brodnik ZD, Ferris MJ, Jones SR, Espana RA.. ACS Chem Neurosci. 2017;8(2):281-289.

alpha6beta2 subunit containing nicotinic acetylcholine receptors exert opposing actions on rapid dopamine signaling in the nucleus accumbens of rats with high-versus low-response to novelty. Siciliano CA, McIntosh JM, Jones SR, Ferris MJ.. Neuropharmacology. 2017;126():281-291.

Differential modulation of striatal dopamine release by nicotinic receptors in adolescent and adult rats [abstract]. Ferris M, Fennell A, Sexton L.. Neuropsychopharmacology. 2017;43(Suppl 1):S262.

The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine. Karkhanis AN, Beveridge TJ, Blough BE, Jones SR, Ferris MJ.. Drug Alcohol Depend. 2016;166():51-60.

Protein kinase C beta regulates the D2-like dopamine autoreceptor. Luderman KD, Chen R, Ferris MJ, Jones SR, Gnegy ME.. Neuropharmacology. 2015;89():335-341.

Greater ethanol inhibition of presynaptic dopamine release in C57BL/6J than DBA/2J mice: role of nicotinic acetylcholine receptors. Yorgason JT, Rose JH, McIntosh JM, Ferris MJ, Jones SR.. Neuroscience. 2015;284():854-864.

Differential influence of dopamine transport rate on the potencies of cocaine, amphetamine, and methylphenidate. Calipari ES, Ferris MJ, Siciliano CA, Jones SR.. ACS Chem Neurosci. 2015;6(1):155-162.

Adaptations of presynaptic dopamine terminals induced by psychostimulant self-administration. Siciliano CA, Calipari ES, Ferris MJ, Jones SR.. ACS Chem Neurosci. 2015;6(1):27-36.

A single amphetamine infusion reverses deficits in dopamine nerve-terminal function caused by a history of cocaine self-administration. Ferris MJ, Calipari ES, Rose JH, Siciliano CA, Sun H, Chen R, Jones SR.. Neuropsychopharmacology. 2015;40(8):1826-1836.

Optogenetic versus electrical stimulation of dopamine terminals in the nucleus accumbens reveals local modulation of presynaptic release. Melchior JR, Ferris MJ, Stuber GD, Riddle DR, Jones SR.. J Neurochem. 2015;134(5):833-844.

Cocaine self-administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine. Siciliano CA, Ferris MJ, Jones SR.. Eur J Neurosci. 2015;42(4):2091-2096.

Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum. Yorgason JT, Calipari ES, Ferris MJ, Karkhanis AN, Fordahl SC, Weiner JL, Jones SR.. Neuropharmacology. 2015;101():471-479.

Dissociating appetitive and consummatory behavior in drug use prone and resistant animals [abstract]. Siciliano C, Gabriele A, Jones S, Ferris M.. Neuropsychopharmacology. 2015;40(Suppl 1):S251-S252.

Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations. Calipari ES, Ferris MJ, Melchior JR, Bermejo K, Salahpour A, Roberts DC, Jones SR.. Addict Biol. 2014;19(2):145-155.

Frequency-dependent effects of ethanol on dopamine release in the nucleus accumbens. Yorgason JT, Ferris MJ, Steffensen SC, Jones SR.. Alcohol Clin Exp Res. 2014;38(2):438-447.

Extended access of cocaine self-administration results in tolerance to the dopamine-elevating and locomotor-stimulating effects of cocaine. Calipari ES, Ferris MJ, Jones SR.. J Neurochem. 2014;128(2):224-232.

Intermittent cocaine self-administration produces sensitization of stimulant effects at the dopamine transporter. Calipari ES, Ferris MJ, Siciliano CA, Zimmer BA, Jones SR.. J Pharmacol Exp Ther. 2014;349(2):192-198.

Biphasic mechanisms of amphetamine action at the dopamine terminal. Siciliano CA, Calipari ES, Ferris MJ, Jones SR.. J Neurosci. 2014;34(16):5575-5582.

Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission. Daigle TL, Ferris MJ, Gainetdinov RR, Sotnikova TD, Urs NM, Jones SR, Caron MG.. Neuropsychopharmacology. 2014;39(10):2450-2462.

Dopamine transporters govern diurnal variation in extracellular dopamine tone. Ferris MJ, Espana RA, Locke JL, Konstantopoulos JK, Rose JH, Chen R, Jones SR.. Proc Natl Acad Sci U S A. 2014;111(26):E2751-2759.

Sustained N-methyl-D-aspartate receptor hypofunction remodels the dopamine system and impairs phasic signaling. Ferris MJ, Milenkovic M, Liu S, Mielnik CA, Beerepoot P, John CE, Espana RA, Sotnikova TD, Gainetdinov RR, Borgland SL, Jones SR, Ramsey AJ.. Eur J Neurosci. 2014;40(1):2255-2263.

Individual differences in the modulation of dopamine signals in the ventral striatum by nicotinic acetylcholine receptors [abstract]. Ferris M, Jones S.. Neuropsychopharmacology. 2014;39(Suppl 1):S611.

Biphasic mechanisms of amphetamine action at the dopamine terminal [abstract]. Siciliano C, Calipari E, Ferris M, Chen R, Jones S.. FASEB J. 2014;28(1 Suppl):661.4.

Amphetamine mechanisms and actions at the dopamine terminal revisited [journal club article]. Calipari ES, Ferris MJ.. J Neurosci. 2013;33(21):8923-8925.

Examining the complex regulation and drug-induced plasticity of dopamine release and uptake using voltammetry in brain slices. Ferris MJ, Calipari ES, Yorgason JT, Jones SR.. ACS Chem Neurosci. 2013;4(5):693-703.

Paradoxical tolerance to cocaine after initial supersensitivity in drug-use-prone animals. Ferris MJ, Calipari ES, Melchior JR, Roberts DC, Espana RA, Jones SR.. Eur J Neurosci. 2013;38(4):2628-2636.

Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine transporter. Calipari ES, Ferris MJ, Zimmer BA, Roberts DC, Jones SR.. Neuropsychopharmacology. 2013;38(12):2385-2392.

Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression. Calipari ES, Ferris MJ, Salahpour A, Caron MG, Jones SR.. Nat Commun. 2013;4():2720.

Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate. Ferris MJ, Calipari ES, Mateo Y, Melchior JR, Roberts DCS, Jones SR.. Neuropsychopharmacology. 2012;37(7):1708-1716.

Effects of the histamine H1 receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward. Oleson EB, Ferris MJ, Espana RA, Harp J, Jones SR.. Eur J Pharmacol. 2012;683(1-3):161-165.

Cocaine-insensitive dopamine transporters with intact substrate transport produced by self-administration. Ferris MJ, Mateo Y, Roberts DCS, Jones SR.. Biol Psychiatry. 2011;69(3):201-207.

Hyperdopaminergic tone in HIV-1 protein treated rats and cocaine sensitization. Ferris MJ, Frederick-Duus D, Fadel J, Mactutus CF, Booze RM.. J Neurochem. 2010;115(4):885-896.

In vivo microdialysis in awake, freely moving rats demonstrates HIV-1 Tat-induced alterations in dopamine transmission. Ferris MJ, Frederick-Duus D, Fadel J, Mactutus CF, Booze RM.. Synapse. 2009;63(3):181-185.

The human immunodeficiency virus-1-associated protein, Tat1-86, impairs dopamine transporters and interacts with cocaine to reduce nerve terminal function: a no-net-flux microdialysis study. Ferris MJ, Frederick-Duus D, Fadel J, Mactutus CF, Booze RM.. Neuroscience. 2009;159(4):1292-1299.

Neurotoxic profiles of HIV, psychostimulant drugs of abuse, and their concerted effect on the brain: current status of dopamine system vulnerability in neuroAIDS. Ferris MJ, Mactutus CF, Booze RM.. Neurosci Biobehav Rev. 2008;32(5):883-909.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Physiology & Pharmacology

Mark John Ferris, Ph.D.

Mark John Ferris, Ph.D.

Assistant Professor, Physiology & Pharmacology
Substance Addiction& Abuse Ctr

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