A Randomized, Double-Blind, Placebo-Controlled and Delayed-Start Study of LY3314814 in Mild Alzheimer’s Disease Dementia

What we are studying

The purpose of this research study is to see if the investigational drug, LY3314814 can slow the progression of Alzheimer’s disease. LY3314814 is an investigational drug. This means it has not been approved by the U.S. Food and Drug Administration (FDA). Drugs that do not have approval by the FDA cannot be sold or prescribed by your physician. In this study LY3314814 will be compared to a placebo. A placebo is a substance, like a sugar pill, that is not thought to have any effect on your disease or condition. In this study you will either receive the active study medication, LY3314814 or a placebo which is not active. Placebos are used in research studies to see if the drug being studied really does have an effect.

Who is Eligible

  • Genders:
    • Men
    • Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 55 - 85

Eligibility Criteria

  • Diagnosis of mild AD
  • Stable medications for the past 30 days
  • Women must not be of child bearing potential
  • Have a reliable study partner
  • Must be able to read
  • Write with sight and hearing ability to complete study tests.

What is involved

  • 7 skin exams
  • 5 eye exams
  • 3 PET scans or lumbar punctures
  • 3 MRI scans
  • 4 telephone interviews
  • At least 27 in-person visits


Screening 1, 8, 12, 16, 21, 25, 29, 30 & follow-up: $50 each. Screening 2: $25. Screening 3: $75. Visit 3, 4, 5, 10, 14, 15, 17, 18, 23, 27, & 28: $20 each. Visit 6, 7, 11, 19, 20, & 24: $30 each. PET scan OR lumbar puncture on visit 15, 29, or 30: $75.

Contact Information

Study Coordinator
Tim Collare
[email protected]
Principal Investigator
Mary F. Lyles, MD

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Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.