Study of the Effects of Vitamin D on Muscle Function (EVIDENCE Study)

What we are studying

The purpose of this research study is to see if vitamin D changes your muscle function and your risk of falling. The study lasts 12 months and you will have up to 2 visits to see if you qualify. If you do, you will randomly be assigned either to the vitamin D group and you will be given a 12 month supply of 2,000 IU of vitamin D3 and will be asked to take one per day. If you are placed into the placebo group, you will be given a 12 month supply of the placebo and will be asked to take one per day. You will be asked to come back after 4 months and again after 12 months to complete the study.

Who is Eligible

  • Genders:
    • Men
    • Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 65 - 89

Eligibility Criteria

  • You cannot be taking a prescription for vitamin D or more than 1000 IU of vitamin D already
  • You cannot be using insulin to control diabetes
  • You cannot have cancer that has required treatment in the last year
  • You cannot have a history of kidney stones in the last 5 years
  • You must have difficulty doing daily tasks such as getting in or out of chair or walking up stairs

What is involved

  • Up to 6 visits over 13 months that involve blood draws to test for vitamin D
  • Physical performance testing
  • Memory testing
  • Possible muscle sampling


Participants receive up to $200 for completing all study visits & an additional $200 is given if muscle samples are completed. A participant who withdraws from the study will receive $40 for each completed visit & $100 for each completed muscle sample.

Contact Information

Study Coordinator
Michelle Gordon
[email protected]
Principal Investigator
Denise Houston, PhD, RD

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.