Study Looking at Drugs to Improve the Treatment of Ewing Sarcoma

What we are studying

In this study, researchers want to find out if we can improve the treatment for this disease by adding another drug called Topotecan to the 5 drugs used in standard treatment. We chose the drug Topotecan because the combination of Topotecan and Cyclophosphamide has been found to be useful in treating some subjects with Ewing sarcoma when it has come back after treatment (recurrence). The combination of vincristine/topotecan/cyclophosphamide (VTC) has been well-tolerated in people with other types of sarcoma. A recent COG study added VTC to standard therapy for localized Ewing sarcoma and the early results indicate that VTC can be used in this way.

Who is Eligible

  • Genders:
    • Men
    • Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 8 - 18

Eligibility Criteria

  • Diagnosed with Non-metastatic Ewing Sarcoma

What is involved

  • Chemotherapy treatment
  • Surgery
  • Radiation treatment
  • 12 week cycle



Contact Information

Study Coordinator
Graham Keyes
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Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.