Pelvic Irradiation w/without Weekly Cisplatin Uterine

What we are studying

The main purpose of this study is to compare radiation therapy in combination with weekly treatment with the chemotherapy drug cisplatin to the standard treatment for this type of cancer. The standard treatment for patients with your type of cancer is radiation therapy alone. Radiation therapy is a cancer treatment that uses radiation beams from outside your body, or radioactive seeds or pellets placed directly into the tissue to kill cancer cells. Radiation therapy alone has not been very effective in treating large tumors that recur (come back) in the pelvis, lymph nodes or vagina. Radiation therapy in combination with weekly treatment with the chemotherapy drug cisplatin has been found to be very effective in treating patients with advanced cervical cancers. Another purpose of the study is to evaluate the side effects of the combination of radiation therapy and cisplatin.

Who is Eligible

  • Genders:
    • Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 18+

Eligibility Criteria

  • All patients must have undergone complete hysterectomy and bilateral salpingo-oophorectomy at the time of the original therapy for their uterine carcinoma
  • Patients must have a biopsy with histologically confirmed diagnosis of recurrent endometrial cancer confined to the pelvis and/or vagina and no evidence of extrapelvic disease

What is involved

  • History and physical examination which may include pelvic examination
  • Blood tests to measure blood counts;blood mineral levels; and check liver and kidney function
  • Chest imaging (x-ray); if x-ray is abnormal a CT scan of the chest is required
  • CT scan of the abdomen and pelvis to measure detectable tumor
  • EKG (Electrocardiogram) or electrical tracing of your heart beat

Compensation

None

Contact Information

Study Coordinator
Cindy Miller
Email
[email protected]
Phone
-6770
Principal Investigator
Samuel Lentz, MD

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Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.